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[Shin-Min Joon, Edaily Reporter] Huonslab a subsidiary of Huons Global announced the study results confirming the potential for switching administrations of antibodies and antibody drug conjugates (ADCs) to subcutaneous (SC) formulation with recombinant human hyaluronidase.
Huonslab CI. (Image 릴게임종류 =Huonslab)
Huonslab today announced that its abstract has been selected for presentation on March 4 (local time) at the 2026 Annual Meeting of the American Society for 야마토게임다운로드 Clinical Pharmacology and Therapeutics (ASCPT) in Colorado, USA. The abstract covers a preclinical study assessing the applicability of human hyaluronidase ‘HyDIFFUZE’ for antibodies and ADCs.
야마토게임예시Huonslab has conducted pharmacokinetics (PK) studies applying HyDIFFUZE to 11 monoclonal antibodies (mAbs) and 3 ADCs, comparing the original formulations with those incorporating the proprietary 야마토게임하기 HyDIFFUZE platform. The results indicated that HyDIFFUZE consistently enhanced SC delivery.
Evaluation in Sprague-Dawley rats compared original high dose antibody and ADC formulations with t 릴게임오션파라다이스 hose co-formulated with HyDIFFUZE. The analysis demonstrated that the HyDIFFUZE formulations increased the area under the curve (AUC) by 116~162% and the maximum plasma concentration (Cmax) by 113~170% compared with the original formulations.
In addition, even when the antibody dose was reduced approximately 25% in the HyDIFFUZE based formulation comparable levels of AUC and Cmax were observed.
These findings showed that HyDIFFUZE addresses key challenges of SC administration by enhancing drug dispersion and maintaining equivalent exposure even at reduced dose. Consequently HyDIFFUZE demonstrated the potential to be a broadly applicable SC delivery platform not only for mAbs and ADCs but also for biologics such as nucleic acids, bi specifics and PROTACs.
Huonslab’s official stated “The HyDIFFUZE platform technology holds significant potential for developing SC formulations across a wide range of modalities. Moving forward we will remain committed to further expand its application.”
In December 2025, Huonslab has submitted a Biologics License Application (BLA) to the Ministry of Food and Drug Safety for its natural human hyaluronidase HYDIZYME manufactured using Huonslab’s proprietary HyDIFFUZE technology.
Upon approval Huonslab expects HYDIZYME to be utilized as a stand alone drug product in aesthetics, dermatology, pain management and edema treatment upon launch.
신민준 (adonis@edaily.co.kr)
Huonslab CI. (Image 릴게임종류 =Huonslab)
Huonslab today announced that its abstract has been selected for presentation on March 4 (local time) at the 2026 Annual Meeting of the American Society for 야마토게임다운로드 Clinical Pharmacology and Therapeutics (ASCPT) in Colorado, USA. The abstract covers a preclinical study assessing the applicability of human hyaluronidase ‘HyDIFFUZE’ for antibodies and ADCs.
야마토게임예시Huonslab has conducted pharmacokinetics (PK) studies applying HyDIFFUZE to 11 monoclonal antibodies (mAbs) and 3 ADCs, comparing the original formulations with those incorporating the proprietary 야마토게임하기 HyDIFFUZE platform. The results indicated that HyDIFFUZE consistently enhanced SC delivery.
Evaluation in Sprague-Dawley rats compared original high dose antibody and ADC formulations with t 릴게임오션파라다이스 hose co-formulated with HyDIFFUZE. The analysis demonstrated that the HyDIFFUZE formulations increased the area under the curve (AUC) by 116~162% and the maximum plasma concentration (Cmax) by 113~170% compared with the original formulations.
In addition, even when the antibody dose was reduced approximately 25% in the HyDIFFUZE based formulation comparable levels of AUC and Cmax were observed.
These findings showed that HyDIFFUZE addresses key challenges of SC administration by enhancing drug dispersion and maintaining equivalent exposure even at reduced dose. Consequently HyDIFFUZE demonstrated the potential to be a broadly applicable SC delivery platform not only for mAbs and ADCs but also for biologics such as nucleic acids, bi specifics and PROTACs.
Huonslab’s official stated “The HyDIFFUZE platform technology holds significant potential for developing SC formulations across a wide range of modalities. Moving forward we will remain committed to further expand its application.”
In December 2025, Huonslab has submitted a Biologics License Application (BLA) to the Ministry of Food and Drug Safety for its natural human hyaluronidase HYDIZYME manufactured using Huonslab’s proprietary HyDIFFUZE technology.
Upon approval Huonslab expects HYDIZYME to be utilized as a stand alone drug product in aesthetics, dermatology, pain management and edema treatment upon launch.
신민준 (adonis@edaily.co.kr)
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